TB-500
TB-500 is a synthetic fragment of Thymosin β₄ (Tβ₄), a naturally occurring 43-amino-acid peptide involved in cell migration and actin regulation. Research has focused on its roles in cytoskeletal organization, angiogenesis, wound closure, and inflammatory signaling in multiple animal and cell models.
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The information provided is for educational and informational purposes only and should not be interpreted as medical advice. All products described herein are intended strictly for laboratory and research use. They are not approved for human or veterinary administration, and should only be handled by qualified professionals in controlled research environments. Any clinical research must be conducted under the supervision and approval of an Institutional Review Board (IRB), and all preclinical studies must adhere to Institutional Animal Care and Use Committee (IACUC) guidelines in accordance with the Animal Welfare Act (AWA). Users are encouraged to conduct their own due diligence, referencing trusted scientific sources and verifying all information independently before making any purchasing or experimental decisions.
⚠️ Notice: All products are sold for laboratory and research purposes only. They are not intended for diagnostic, therapeutic, or personal use under any circumstances.
TB-500
Overview
TB-500 is a synthetic fragment of Thymosin β₄ (Tβ₄), a naturally occurring 43-amino-acid peptide involved in cell migration and actin regulation. Research has focused on its roles in cytoskeletal organization, angiogenesis, wound closure, and inflammatory signaling in multiple animal and cell models.
Mechanism of Action
- Actin-binding and polymerization: Observed to influence cell migration and tissue-remodeling processes through regulation of G-actin availability.
- VEGF and angiogenesis: Associated with increased vascular endothelial growth factor expression and capillary-network formation in preclinical studies.
- Anti-apoptotic signaling: Reported activation of integrin-linked kinase and PI3K/Akt pathways correlated with reduced programmed-cell-death markers.
- Inflammation control: Observed down-regulation of NF-κB and suppression of pro-inflammatory cytokines in controlled experiments.
- Stem-cell recruitment: Reported mobilization of progenitor cells to injury sites in animal models.
Key Research Findings
1. Tissue Repair and Wound Closure
- Topical and systemic Tβ₄ or TB-500 were observed to accelerate dermal-wound-closure kinetics and epithelial reorganization (Malinda 1999; Smart 2007).
- Increased fibroblast migration and collagen deposition were reported in both in-vitro and in-vivo experimental settings.
2. Angiogenesis and Perfusion
- Demonstrated increased endothelial sprouting and capillary density with observed maintenance of tissue viability under ischemic stress (Sosne 2010; Goldstein 2015).
3. Muscle, Tendon, and Ligament Studies
- Observed activation of satellite cells and myofiber regeneration following induced trauma (Crockford 2010).
- Reported modulation of tendon-tensile properties and collagen alignment in rodent Achilles and flexor-tendon models (Bock-Marek 2014).
4. Cardiac and Vascular Research
- In myocardial-infarction models, associated with reduced fibrotic deposition and maintenance of ventricular contractility (Smart 2007).
- Observed cardiomyocyte-survival signaling via ILK–Akt activation (Huff 2001).
5. Neural and Corneal Models
- Reported corneal re-epithelialization and neurite outgrowth in ocular-injury studies (Sosne 2010).
- Observed reduction of neuroinflammatory markers and increased neuronal-process extension in ischemic-brain models.
Research References
- Malinda K.M. et al. (1999) — Endothelial migration and angiogenesis.
- Smart N. et al. (2007) — Cardiac regeneration after ischemia.
- Sosne G. et al. (2010) — Corneal wound healing and inflammation.
- Goldstein A.L., Hannappel E. (2015) — Functional roles of Tβ₄ in repair and angiogenesis.
- Huff T. et al. (2001) — Actin regulation and cell motility.
- Crockford D. (2010) — Review of TB-500 research in tissue regeneration models.
- Bock-Marek A. et al. (2014) — Tendon regeneration in rat models.
Product Specifications
C₂₂₁H₃₆₇N₆₇O₁₃₇S
4963.49 g/mol
77591-33-4
Thymosin Beta-4 Fragment; Tβ4 Fragment
Lyophilized powder
Keep refrigerated upon reconstitution
Soluble in sterile water and 0.9% NaCl solution
Research-use only. All information summarizes preclinical and in-vitro studies and is not intended for diagnostic, therapeutic, or personal use.
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