BPC-157
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protective protein found in gastric tissue. Research has investigated its cellular-repair, angiogenic, anti-inflammatory, and neuroprotective properties within preclinical systems. Experimental evidence indicates that BPC-157 may influence vascular, connective-tissue, and neural processes through modulation of several molecular signaling pathways in non-clinical contexts only.
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The information provided is for educational and informational purposes only and should not be interpreted as medical advice. All products described herein are intended strictly for laboratory and research use. They are not approved for human or veterinary administration, and should only be handled by qualified professionals in controlled research environments. Any clinical research must be conducted under the supervision and approval of an Institutional Review Board (IRB), and all preclinical studies must adhere to Institutional Animal Care and Use Committee (IACUC) guidelines in accordance with the Animal Welfare Act (AWA). Users are encouraged to conduct their own due diligence, referencing trusted scientific sources and verifying all information independently before making any purchasing or experimental decisions.
⚠️ Notice: All products are sold for laboratory and research purposes only. They are not intended for diagnostic, therapeutic, or personal use under any circumstances.
BPC-157
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protective protein found in gastric tissue. Research has investigated its cellular-repair, angiogenic, anti-inflammatory, and neuroprotective properties within preclinical systems. Experimental evidence indicates that BPC-157 may influence vascular, connective-tissue, and neural processes through modulation of several molecular signaling pathways in non-clinical contexts only.
Mechanistic Insights
- Nitric-oxide (NO) signaling: Regulation of vascular tone and microcirculatory dynamics in injury-response models.
- Growth-factor interaction: Influence on VEGF, FGF, and TGF-β signaling associated with angiogenic and collagen-formation processes.
- Cytoskeletal regulation: Adjustment of fibroblast migration and actin-filament organization in cell-culture assays.
- Neurotransmitter modulation: Observed interaction with dopaminergic and serotonergic pathways in stress and neurotoxicity models.
- Inflammatory signaling: Suppression of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and NF-κB activation in preclinical studies.
Key Research Observations
Musculoskeletal and Connective-Tissue Models
- Rodent and equine studies have reported modulation of tendon-to-bone interface remodeling, collagen organization, and tissue-load response under experimental conditions (Seiwerth et al., 2021; Sikiric et al., 2016).
- In fibroblast cultures, BPC-157 increased migration rate and collagen-type I gene expression, consistent with ECM reorganization in in-vitro systems.
Angiogenesis and Vascular Regulation
- Preclinical research shows upregulation of VEGF and angiopoietin-1, correlating with endothelial protection under oxidative stress (Hsieh et al., 2020).
- Animal models have demonstrated maintenance of capillary density and improved reperfusion dynamics following induced ischemia (Chang et al., 2014).
Gastrointestinal and Organ Studies
- In-vivo data indicate support of gastric-mucosal and intestinal-barrier integrity following experimental toxic exposure (Rashed et al., 2021), linked to modulation of NO synthesis and inflammatory mediators in controlled research settings.
Neurobiological Research
- In rodent models, BPC-157 has been observed to enhance axonal sprouting, reduce oxidative neuronal injury, and stabilize dopaminergic activity during neurotoxic challenge.
- Associated modulation of stress-related biomarkers and behavioral indices has been noted in preclinical neurobehavioral paradigms.
Inflammatory and Cytoprotective Assays
- Demonstrated down-regulation of NF-κB and attenuation of pro-inflammatory cytokine signaling in tissue-injury models; reduced oxidative-damage markers suggest potential antioxidant and anti-apoptotic activity under laboratory conditions.
Cardiovascular and Metabolic Investigations
- In experimental cardiac-injury models, BPC-157 has been associated with preservation of myocardial perfusion and smaller necrotic regions compared with untreated controls.
- Limited animal data indicate modulation of glucose and lipid-metabolic signaling pathways; the relevance of these findings remains strictly investigational.
Research References
- Seiwerth S. et al. (2018–2021) — “BPC-157 and angiogenic growth factor modulation in tendon healing.”
- Sikiric P. et al. (2016) — “Stable gastric pentadecapeptide BPC-157 in wound healing and organ protection models.”
- Chang C.H. et al. (2014) — “NO-mediated angiogenic mechanisms of BPC-157 in ischemic injury.”
- Hsieh M. et al. (2020) — “Microvascular endothelial protection by BPC-157.”
- Rashed H. et al. (2021) — “Hepatoprotective and antioxidative effects of BPC-157 in toxic models.”
- Sikiric P., Seiwerth S. (2013–2021) — Comprehensive reviews on multi-organ protective mechanisms.
Product Specifications
C₆₂H₉₈N₁₆O₂₂
1419.5 g/mol
137525-51-0
PL 14736; Body Protection Compound 157
Lyophilized powder
Keep refrigerated upon reconstitution
Soluble in sterile water and 0.9% NaCl solution
Research-use only. All information summarizes preclinical and in-vitro studies and is not intended for diagnostic, therapeutic, or personal use.
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