KPV
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH). Research has investigated its anti-inflammatory, epithelial-barrier, and immunomodulatory properties in preclinical systems, without the pigmentary or endocrine effects associated with full-length α-MSH. KPV has been studied across gastrointestinal, dermal, and neuroimmune models for its ability to modulate NF-κB signaling, rebalance cytokine output, and support tissue homeostasis.
Select Dosage
Purchase Options
Bulk Discounts
The information provided is for educational and informational purposes only and should not be interpreted as medical advice. All products described herein are intended strictly for laboratory and research use. They are not approved for human or veterinary administration, and should only be handled by qualified professionals in controlled research environments. Any clinical research must be conducted under the supervision and approval of an Institutional Review Board (IRB), and all preclinical studies must adhere to Institutional Animal Care and Use Committee (IACUC) guidelines in accordance with the Animal Welfare Act (AWA). Users are encouraged to conduct their own due diligence, referencing trusted scientific sources and verifying all information independently before making any purchasing or experimental decisions.
⚠️ Notice: All products are sold for laboratory and research purposes only. They are not intended for diagnostic, therapeutic, or personal use under any circumstances.
KPV
Overview
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH). Research has investigated its anti-inflammatory, epithelial-barrier, and immunomodulatory properties in preclinical systems, without the pigmentary or endocrine effects associated with full-length α-MSH. KPV has been studied across gastrointestinal, dermal, and neuroimmune models for its ability to modulate NF-κB signaling, rebalance cytokine output, and support tissue homeostasis.
Key Research Areas
1. Anti-Inflammatory Modulation
- Preclinical studies demonstrate inhibition of NF-κB activation, a central regulator of inflammatory transcription (Grieco 2013).
- Reported decreases in TNF-α, IL-1β, IL-6, and IFN-γ across colitis, dermatitis, arthritis, and sepsis models (Getting 1999; Catania 2000).
- Functions as an endogenous-mimetic anti-inflammatory modulator in laboratory systems, without corticosteroid-type signaling; reductions in oxidative and immune stress markers align with inflammation resolution in experimental models.
2. Gastrointestinal and Epithelial-Barrier Research
- Observed restoration of tight-junction proteins (occludin, claudins) and reduced permeability in epithelial-monolayer assays (Chen 2007).
- Reported suppression of colonic inflammatory activity in IBD-related animal models (Getting 1999, 2001), with associated balanced mucosal immune signaling and stabilized luminal environment in preclinical research.
- Protective effects against antibiotic- or toxin-induced intestinal inflammation have been documented in animal systems.
3. Dermal and Wound-Healing Studies
- Observed attenuation of erythema, edema, and pruritus in inflammatory-skin models including eczema and psoriasis (Bhardwaj 1996; Catania 2000).
- Reported suppression of mast-cell degranulation and histamine release, consistent with modulation of allergic and irritant responses; experimental results indicate accelerated re-epithelialization with ECM-gene upregulation.
4. Immune Modulation and Antimicrobial Activity
- Exhibits intrinsic antimicrobial behavior in vitro against bacterial species such as E. coli and S. aureus (Lipton & Catania 1997).
- Observed rebalancing of innate and adaptive immune responses, limiting hyper- and hypo-reactivity in experimental settings; associated with reduced infection-driven inflammatory signaling in gut and skin models.
5. Cellular Repair and Oxidative-Stress Regulation
- Observed support of microvascular and angiogenic activity, contributing to nutrient and oxygen delivery in stressed tissues (Wang 2020).
- Reported decreases in reactive oxygen species and lipid peroxidation, with evidence of enhanced mitochondrial function across muscle, tendon, mucosal, and organ systems following inflammatory challenge in animal studies.
6. Neuroimmune and Neuroprotective Research
- Observed reductions in neuroinflammatory markers through microglial signaling modulation and antioxidant activity (Caruso 2014).
- Experimental airway models indicate decreased allergic inflammation consistent with melanocortin-pathway engagement; emerging studies suggest possible influence on gut–brain-axis signaling and cognitive parameters under inflammatory stress (strictly preclinical).
7. Endocrine Profile and Laboratory Tolerability
- Unlike α-MSH, KPV shows no pigmentary activity and minimal endocrine disruption in research models; reported as well tolerated across animal studies at examined concentrations.
- Evaluated in oral, topical, and parenteral research configurations within laboratory settings; findings remain nonclinical and investigational.
Research References
- Getting S.J. et al. (1999). J Immunol 163(4):2106–2112.
- Bhardwaj R.S. et al. (1996). J Invest Dermatol 106(3):661–666.
- Catania A. et al. (2000). Endocr Rev 21(5):524–547.
- Grieco P. et al. (2013). Peptides 50:60–66.
- Getting S.J. et al. (2001). Br J Pharmacol 132(1):135–144.
- Chen W. et al. (2007). Am J Physiol-Gastrointest Liver Physiol 293(5):G1140–G1147.
- Al-Obeidi F., Hruby V.J. (1991). Peptide Res 4(5):277–283.
- Lipton J.M., Catania A. (1997). Adv Exp Med Biol 433:185–192.
- Caruso C. et al. (2014). Front Cell Neurosci 8:420.
- Wang L. et al. (2020). Mol Med Rep 22(1):571–580.
Product Specifications
C₁₆H₂₆N₄O₄
338.41 g/mol
81773-34-6
Lys-Pro-Val; α-MSH(11–13) Fragment
Lyophilized powder
Keep refrigerated upon reconstitution
Soluble in sterile water and 0.9% NaCl solution
Research-use only. All information summarizes preclinical and in-vitro studies and is not intended for diagnostic, therapeutic, or personal use.
Frequently Asked Questions
Get answers to common questions about KPV and our research peptides.
Have Questions About KPV?
Get in touch with our research team for detailed information and support.